The utility model provides a high-precision automatic adjustment mould. The high-precision automatic adjustment mould comprises a lower die, a location block, polyurethane, side plates, location screws I, a lower die core, location screws II, location rods, an upper die, an upper die fixing plate and an upper die core, wherein the lower die core is arranged in a lower die groove; the side plates I are arranged at the left side and the right side of the lower die core; the side plates II are arranged at the front side and the rear side of the lower die core and connected with the side plates I; the location screws II are arranged at the left side and the right side of the lower die and connected with the side plates I; the location screws I are arranged at the front side and the rear side of the lower die and connected with the side plates II; the polyurethane is arranged at the front end and the rear end of each of the side plates I; the upper die fixing plate is arranged at the upper end of the upper die; the upper die core is arranged at the lower end of the upper die; the location rods are arranged at the four corners of the upper die. The high-precision automatic adjustment mould provided by the utility model is capable of adjusting the wall thicknesses of products according to different materials and is simple in structure, good in sealing effect, stable in quality, capable of increasing product efficiency, and convenient to use.