The utility model provides a prevent pressing two box pharmaceutical packaging boxes, includes box body and lid, and the lid forms sealed locking cooperation with the box body, and the key is: the box body be the hollow structure who encloses by bottom plate and curb plate, be provided with two at least constant head tanks in the box body, the lower terminal surface of constant head tank is connected with the last fixed surface of box body bottom plate, the height that highly is less than or equal to the box body curb plate of constant head tank still is provided with a plurality of strutting arrangement in the box body, strutting arrangement's lower terminal surface is connected with the last fixed surface of box body bottom plate, strutting arrangement's the height that highly is less than or equal to the box body curb plate. Can put two kinds of medicines need taking simultaneously respectively in a constant head tank, appear leaking the phenomenon of obeying in the time of can avoiding the patient to use medicine, simple structure, low in manufacturing cost is honest and clean, and is capacious, convenient and fast when taking the medicine. Strutting arrangement plays supporting role, can prevent the medicine preserve or the transportation in pressure too big and make the pharmaceutical packaging box be out of shape, the medicine is damaged by pressure.