The utility model discloses a tired device of reaction detection maincenter based on pupil is set a camera, include the binocular camera who provides the lighting device of uniform illumination, the photic stimulator that provides relative highlight light source and the two mesh pupil images of shooting for people's eye, its characterized in that, binocular camera's image output end is connected with the image input of capture card, the image output end of capture card is equipped with the pupil caliber, the pupil touchstone S -parameter output end of pupil caliber is connected with the signal converter who becomes the pupil parametric switch signal of telecommunication, signal converter's signal output part be equipped with reaction numerical value that the pupil of handling and will handle the gained to the signal of telecommunication set a camera with by perhaps colony's reference value processing module of carrying out the comparison of survey person basis value, processing module's output as a result is connected with output device, has the fatigue of detection object, evaluatees efficient advantage.