The utility model provides a hot rerum natura measurement system of hydrate, the hot rerum natura measurement system of includes high -pressure batch autoclave, temperature regulating device, compression forming device, air feeder, measuring device and data acquisition device. Temperature regulating device includes the thermostatted water bath cabinet, and high -pressure batch autoclave places at the water bath with thermostatic control incasement. Compression forming device includes the piston, and it has the inlet to open on the high -pressure batch autoclave inner wall at piston rear portion, and the inlet is connected with the booster pump. Measuring device includes thermal analyzer, and thermal analyzer's probe inserts the sample intermediate position. When measuring through above -mentioned hot rerum natura measurement system of hydrate, at first put into the sample again then pass through the hot rerum natura that thermal analyzer measured the hydrate. Above -mentioned hot rerum natura measurement system of hydrate, the hydrate both sides receive the extrusion simultaneously, and the probe can not buckled, can reduce the probe and damage. Simultaneously, the hydrate uniformity is good, and measurement accuracy is high.