The utility model relates to a high pressure medical pump body connecting device, it includes pump body connection seat, two chucking mechanisms and relieves the mechanism, and the pump body connection seat has pump body storage tank, and next lateral wall has the breach respectively, and two breachs set up relatively, two chucking mechanisms set up relatively in outside two lateral walls of pump body connection seat, each chucking mechanism includes the trip, piece and U type mounting reset, relieve the below of establishment of institution in the pump body connection seat to correspond two chucking mechanisms. The chucking state that the mechanism relieved two chucking mechanisms is relieved to two the chucking mechanism chucking pump body in pump body connection seats, and the pump body can automatically withdraw from from the pump body connection seat. The utility model provides a high pressure medical pump body connecting device simple structure, easy to operate to can fix the pump body on equipment, avoids the pump body to come off when using firmly on the slave unit.