The utility model discloses a PICC waterproof sleeve, in using, at first patient PICC piercing part position is emboliaed with the hand with the adapter sleeve to medical personnel, and with patient PICC piercing part position middle -end position inside the adapter sleeve, medical personnel hold the gasbag again, and with the continuous extruded air bag of hand, in gas that the gasbag formed emited into first air cushion and second air cushion by the intake pipe this moment, under the effect of gas, the messenger wins air cushion and second air cushion and expands gradually, inflation through first air cushion and second air cushion, make the device carry out the soft clip to the patient, when the device reaches the standard value that pressure sensor set for to the dynamics of patient's soft clip, the warning light lights, suggestion medical personnel the device has reached the required requirement of medical personnel to patient's clamp force, medical personnel only needed the hand gassing bag can this moment, this PICC waterproof sleeve, can effectually carry out the soft clip with the device and patient, avoided patient PICC piercing part position the phenomenon emergence that blood flow has some setbacks to appear, play the guard action to the patient.