The utility model discloses a can be applied to medical biological antibiotic sanitary material that absorbs water and the preparation method who wraps up material, sanitary pad, sanitary towel, panty -shape diapers. From top to bottom the stromatolite sets up antibiotic liquidity surface course, antibacterial function nature absorption core, liquid -tight nature bottom in proper order, antibiotic liquidity surface course is the non -woven fabrics that individual layer or double -deck biological antiseptic were arrange in order, is biological antiseptic epsilon polylysine and/or epsilon among polylysine hydrochloric acid, natamycin, the nisin ( nisin ) one kind or several kinds, the bacterinertness includes in absorbing the core: is the biological bactericide epsilon polylysine, epsilon one kind or several kinds of mixtures among polylysine hydrochloric acid, natamycin, the nisin, polymer water absorbing agent, fluff pulp, plant extract, the backing layer is micropore breathable film. This biological antibiotic sanitary material that absorbs water has the advantage that good, the antibacterial register for easy reference of antibiotic persistence is wide, bio -safety nature is high, the anti - rate of oozing is low.