The utility model discloses a bioreactor, include: the plastic width -lock type single -layer sealed packing case comprises a casin, the inside accommodation space who is the hollow, is used for holding the culture solution of box, fixed set up in the box, be used for driving and wait the rotatory rotating assembly of bone tissue axial that cultivates, fixed set up on the outer wall of box and motor that rotation axis and rotating assembly are connected, the silo is arranged to the strip of setting on box inner wall bottom, the bin outlet that the silo communicates is arranged to the setting on the box outer wall and with the strip, the setting on the outer wall of box and with the air inlet of accommodation space intercommunication, the setting on the outer wall of box and with the gas vent of accommodation space intercommunication. The utility model discloses the developments in the well mould apery and the environment of the temperature and the liquid velocity of flow have been realized still including the three -dimensional stereoscopic cultivate who rotates this dimension for train the bone tissue that comes out and more approach human crude skeleton.