The utility model discloses a medical operating room skid resistance and breathable protection leg cover, including thigh cover, shank cover and podotheca, thigh cover, shank cover and podotheca from the top down link for whole in proper order, thigh cover top is open -top, the folding inner chamber that forms of open -top department, the inner chamber embeds an elastic cord, along the position in inner chamber side until podotheca department, the opening setting is torn to draw and is press -offed, the podotheca is equipped with an inner chamber with the the first part of of shank cover juncture, it has the elastic cord to embed in the inner chamber, the podotheca bottom is double -deck callus on the sole, and its upper strata is the elastic layer, and there is non -slip texture's skid resistant course the lower floor bottom for the suppression. The utility model discloses simple structure, the design is whole close, and more traditional leg cover is compared, and protection nature, gas permeability are better, guarantee in the operation of long period, the good travelling comfort of person of giving the wearing, simultaneously, more reasonable and humanized design for wear to take off more convenient and fast, avoid secondary pollution.