The utility model discloses an antibiotic corrugated container board of environment -friendly mould proof, including base stock, facial tissue and the flute core of bonding between base stock and facial tissue, it has mould proof granule and adsorbed particle to adsorb through electrostatic action on the two sides of base stock and facial tissue to the coating has a waterproof coating, seals mouldproof granule and adsorbed particle on corresponding base stock and facial tissue through the waterproof coating, produces simple process, and the quality is light. The mould proof granule can keep the dry fungus growth that just restraines of cardboard, and adsorbed particle can adsorbing peculiar smell. The waterproof coating can prevent that the steam entering from causing the anti towards theeffect reduction of cardboard, makes the cardboard can keep due compressive strength. The coating has the wearing layer on the waterproof coating of facial tissue upper surface, increases wear resistance. The coating has volatility mould -proof coated on the waterproof coating of base stock lower surface, can slowly release antibiotic mould proof active ingredient, plays the mould proof bacteriostasis to the local space in the packing box.