The utility model provides a shaker screen seal structure belongs to the petroleum drilling equipment field, including sifting bed, rubber seal strip, screw and screen cloth with be used for the piecethat compresses tightly of whole pressing rubber sealing strip, the rubber seal strip is equipped with the recess that the installation compressed tightly and extrudees the arched protrusion portionbetween screen cloth and sifting bed, and the rubber seal strip be the plane with the contact surface of sifting bed, and the screw passes the recess that compresses tightly piece and rubber seal strip and is fixed in on the sifting bed. The utility model provides a shaker screen seal structure, the leakproofness is good, and the constant intensity is high, and seal structure is difficult to damage and became invalid.