The utility model discloses an instrument dust removal device, belongs to the field of instruments, and aims to solve the problems of the conventional instrument dust removal device. The cabinet comprises a cabinet body, the cabinet body is provided with a transparent door plate, the cabinet body comprises an operating room, an operating table is arranged in the operating room, and a plurality offans are arranged at the top of the operating room; the two ash collecting rooms are symmetrically arranged on the two sides of the operating room; the bottoms of the adjacent side walls of the operating room and the two dust collecting rooms are each provided with an air duct, and pipeline fans arranged in the air ducts are used for exhausting air carrying dust in the operating room into the dustcollecting rooms. Two first ash receiving water tanks are arranged on a bottom plate of the operation room, and wheel rollers are arranged in the first ash receiving water tanks and rotate in water;a plurality of atomizing nozzles are arranged at the top of the dust collecting chamber and used for spraying water mist to be combined with dust to fall into a second dust receiving water tank at thebottom of the dust collecting chamber; an air outlet is formed in the top of the ash collecting chamber.