The utility model discloses a turbine million high-pressure valve stop pin hole machining positioning guide device, and relates to a positioning guide device, in particular to a turbine million high-pressure valve stop pin hole machining positioning guide device. The utility model aims to solve the problems that as a universal drill is not numerical control, positioning of the position and the axial size of an inclined hole cannot be guaranteed, a drill bit and a valve inner hole form an included angle of 45 degrees, a machining surface is a curved surface and is not perpendicular to the drillbit, the drill bit deviates, and the initial position of the inclined hole cannot be positioned. The device comprises a positioning block, a positioning sleeve, two screw rods and a supporting block,the two screw rods are arranged in parallel side by side, one end of each screw rod is connected with the positioning block, the other end of each screw rod is connected with the supporting block, and the positioning sleeve is installed on the positioning block. The utility model belongs to the field of machining.