The utility model discloses an efficient UV photo-oxidation catalytic purifier, and belongs to the field of catalytic methods. The device comprises a shell, a waste gas inlet and a waste gas outlet, the waste gas inlet and the waste gas outlet are formed in the two sides of the shell respectively, the interior of the shell is divided into an upper-layer electrical chamber and a lower-layer treatment chamber which are separated through a partition plate, a switch and a circuit breaker are arranged on the shell on the outer side of the electrical chamber, and a ballast is arranged in the electrical chamber; a demisting chamber, a photo-oxidation catalysis chamber and an ozone removal chamber are sequentially arranged between the waste gas inlet and the waste gas outlet of the treatment chamber on the lower layer, and high-energy UV lamp tubes are uniformly arranged in the demisting chamber, the photo-oxidation catalysis chamber and the ozone removal chamber; a wire mesh demister is arranged at the front end of the demisting chamber, a photocatalyst filter screen is arranged in the photo-oxidation catalysis chamber, and an ozone removal filter screen is arranged at the tail end of theozone removal chamber. The water content in the waste gas is reduced by the wire mesh demister device, the photocatalyst filter screen generates a strong catalytic degradation function under the light effect of the high-energy UV lamp tube, and the waste gas finally passes through the ozone removal filter screen.