The utility model relates to the technical field of protective sleeves of refrigerant pipes, and provides an anti-disassembly sleeve and an air conditioner, the anti-disassembly sleeve comprises a first pipe body and a second pipe body, the first pipe body is sleeved on the second pipe body, the inner wall of the first pipe body is provided with a first thread and a limiting body, and the outer wall of the second pipe body is provided with a second thread matched with the first thread; in the linear direction that the second pipe body is sleeved with the first pipe body, the second thread is located in front of the limiting body, and the limiting body is located in front of the first thread; wherein the first thread and the second thread are arranged oppositely. The limiting body is connected with the tooth bottom of the first thread; one end, deviating from the tooth bottom of the first thread, of the limiting body and the inner wall of the first pipe body are arranged at intervals; the end, close to the second thread, of the limiting body is provided with a first cross section, the end, close to the limiting body, of the second thread is provided with a second cross section, thefirst cross section abuts against the second cross section, the purpose of preventing the second thread from rotating is achieved, and then the anti-disassembly function of connection of the first sleeve and the second sleeve is achieved.