The utility model discloses a load switching loss reduction system of a power distribution network, which comprises an intelligent distribution transformer terminal and a plurality of load adjusting devices which are in communication connection with the intelligent distribution transformer terminal and are distributed at each node of the power distribution network, and each load adjusting device is correspondingly connected with an energy-saving compensation device of the power distribution network or a user load. The utility model has the following beneficial effects: the utility model has the following beneficial effects; a plurality of load adjusting devices used for controlling corresponding power distribution network energy-saving compensation devices and user loads to work are arranged at each node of a power distribution network; and each load adjusting device is in communication connection with the intelligent distribution transformer terminal, so that remote intelligent coordination control on each power distribution network energy-saving compensation device and each user load is realized, the line loss rate of the power distribution network is reduced, and the power supply quality of the corresponding transformer area and the power utilization satisfaction degree of the user are improved.