A plastic film folding machine is provided with an interlocking folding mechanism, and a switching reversing mechanism is arranged on the upper portion of the interlocking folding mechanism. Wherein the interlocking folding mechanism comprises two vacuum adsorption folding rollers and two vacuum adsorption reversing rollers I, the splitting and reversing mechanism comprises two groups of longitudinal rotary cutting roller assemblies, each longitudinal rotary cutting roller assembly comprises a friction roller and a longitudinal rotary cutting roller, and a traction roller is arranged above thefriction roller in an abutting manner; a group of transverse rotary cutting roller assemblies are arranged between each group of longitudinal rotary cutting roller assemblies and the vacuum adsorption reversing roller I on the same side, each transverse rotary cutting roller assembly comprises a transverse rotary cutting roller and a vacuum adsorption reversing roller II, and each group of longitudinal rotary cutting roller assemblies is provided with a matched independent feeding system. The plastic film slitting and folding device quickly slits and folds plastic films through the slitting and reversing mechanism and the interlocking and folding mechanism, and has the advantages of being high in automation degree, high in working efficiency, convenient to use, time-saving, labor-saving and the like.