The utility model relates to a self-control safe infusion set which adds a self-control liquid storage pot to the prior art. The self-control safe infusion set automatically closes an infusion tube when the liquid in an infusion bottle is exhausted to prevent air from getting into bodies of patients or to prevent the venous blood of the patients from reversely flowing into the infusion tube, thereby well handling the safety issue of the patients in infusion. The self-control safe infusion set is an ideal infusion set as the safety is improved, the pain of the patients is alleviated, and the nursing work is reduced.