The utility model discloses a blood filtering device, comprising a housing and a combination membrane core. A top cover is connected with a subbase to constitute the housing. A blood inlet and an air exhaust opening are arranged at the top of the top cover and the subbase is provided with a blood outlet. The combination membrane core sealed with the medical grade silicon rubber ring is arranged at the inner housing and is composed of a plurality of stacking filter membrane with layers. Blood infiltrates downwards through the filter membrane layers of the combination membrane core after enters the filtering device. The blood filtering device of the utility model principally used for filtering blood fat, chyle lipoprotein, cholesterol, triglyceride and low-density lipoprotein, etc. in the blood. More than 47% cholesterol and more than 35% triglyceride are decreased through once filtering. Furthermore, other proteins in the blood suffer losslessness. The utility model has high reliability to reimport the treated blood to the patients.