利索-全球专利检索

  1. 登录
  2. 注册
发明公开
CN87100769A 带有2-[2-[N，N-双(2-氯乙基)磷酰二氨基氧基]乙基]基团的新杂环化合物 无效 - 撤回

带有2-[2-[N，N-双(2-氯乙基)磷酰二氨基氧基]乙基]基团的新杂环化合物
摘要：
本发明涉及式(I)化合物及其生产过程。式中R1、R2、R3、R4为氢、C1-C4烷基、2-氯乙基、2-溴乙基、或2-C1-C4烷磺酰氧乙基、R8为氢、C1_6烷基或酰基，R6和R7为氢或一起代表氧原子，或R6为氢，R7为羧基、C1_6烷氧羰基、氨羰基或烷氨羰基，Z为硫、氧、-S-C(R5)2、-O-C-(R5)2-或-NR5-C(R5)2，R5为氢或C1_6烷基。式(I)化合物有抗肿瘤活性。
摘要（英）：

The compounds have the formula …… in which the radicals R1, R2, R3 and R4 denote hydrogen, C1-C4-alkyl, 2-chloroethyl, 2-bromoethyl or 2-C1-C4-alkanesulphonyloxyethyl, R8 is hydrogen, C1-C6-alkyl or an acyl radical, the radicals R6 and R7 are hydrogen or together form an oxygen atom or in which R6 is hydrogen and in this case R7 is a carboxyl group, a C1-C6-alkoxycarbonyl group, an aminocarbonyl group or an alkylaminocarbonyl group, Z is a sulphur atom, an oxygen atom, the group NR5, the group -S-C(R5)2-, -O-C(R5)2- or -NR5-C(R5)2-.

0/0