通过在水溶液中的蛋白质与含有基团活性结合到蛋白质水巯基无载体材料反应的稳定化载体结合的蛋白质，并且通过或具有低于5000的分子量，优选低于2000，优选脂肪族化合物硫化氢的后续动作中，具有至少 收到一个巯基和至少一个另外的巯基，羟基或伯或仲氨基。 优选地，珠状载体材料5和1000微米之间的珠粒径，基于与环氧乙烷基团或cyanbromierte纤维素，琼脂糖或葡聚糖用酶，例如交联聚丙烯酰胺 青霉素实现。 随后，至少0.03重量％附着在游离巯基的载体材料上。 该产品是由在结合的蛋白质的多次重复使用的生物活性的降低的降解特征。

Stabilized carrier-bound proteins by reacting a protein in aqueous solution with a water-mercapto-free carrier material to proteins containing binding-active groups, and by subsequent action of hydrogen sulfide or of preferably aliphatic compounds having a molecular weight below 5000, preferably below 12,000, with at least receive a mercapto group and at least one further mercapto, hydroxy or primary or secondary amino group. Preferably, a bead-like carrier material with a Perldurchmesserzwischen 5 and 1000 is based on a crosslinked polyacrylamide μcm with oxirane or cyanbromierte cellulose, agarose or dextran is reacted with an enzyme such as penicillin acylase. Subsequently, at least 0.03 wt .-% attached to free mercapto groups to the carrier material. The products are characterized by reduced degradation of biological activity in multiple reuse of the bound protein.