发明公开
- 专利标题： Geminally disubstituted indene derivatives, processes for their preparation and pharmaceutical compositions containing them
- 专利标题（中）： 偕二取代的茚衍生物，它们的制备方法和含有它们的药物组合物。
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申请号： EP78300226.4申请日： 1978-08-01
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公开(公告)号： EP0000825A1公开(公告)日： 1979-02-21
- 发明人: Joensson, Aake Nils , Kempe, Tomas Goeran , Mikiver, Lembit , Sparf, Bengt Aake
- 申请人： Kabi AB
- 申请人地址： Lindhagensgatan 133 S-112 87 Stockholm SE
- 专利权人： Kabi AB
- 当前专利权人： Kabi AB
- 当前专利权人地址： Lindhagensgatan 133 S-112 87 Stockholm SE
- 代理机构： Goldin, Douglas Michael
- 优先权： GB3294777 19770805
- 主分类号： C07C91/23
- IPC分类号： C07C91/23 ; C07C93/14 ; C07C135/02 ; A61K31/135 ; C07D295/08
摘要：
New geminally disubstituted indenet are of general formula I
wherein each of R 1 and R 2 is hydrogen or R 1 and R 2 together form a direct bond or an alkylene group -(CH 2 )n-, in which n is an integer from 1 to 4,R 3 is hydrogen, C1-3-alkoxy or halogen, and each of R 4 and R 5 is hydrogen or C1-4-loweralkyl, or R 4 and R 5 togetherform an alkylene group-(CH 2 )m-, in which m is an integer from 3 to 6; and the corresponding amine oxides, quaternary ammonium compounds and salts with physiotog- ically acceptable acids.
The indenes find use in treating incontinence, as a mucous membrane decongestant, as a blood pressure reducing agent, as a vasoconstrictor or as an antireserpine agent.
The indenes may be prepared by process known per se.
wherein each of R 1 and R 2 is hydrogen or R 1 and R 2 together form a direct bond or an alkylene group -(CH 2 )n-, in which n is an integer from 1 to 4,R 3 is hydrogen, C1-3-alkoxy or halogen, and each of R 4 and R 5 is hydrogen or C1-4-loweralkyl, or R 4 and R 5 togetherform an alkylene group-(CH 2 )m-, in which m is an integer from 3 to 6; and the corresponding amine oxides, quaternary ammonium compounds and salts with physiotog- ically acceptable acids.
The indenes find use in treating incontinence, as a mucous membrane decongestant, as a blood pressure reducing agent, as a vasoconstrictor or as an antireserpine agent.
The indenes may be prepared by process known per se.
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