发明公开
EP0028511A1 Cephalosporins, processes for their preparation and microorganisms capable of their production
失效
头孢菌素类，它们的制备方法以及它们的生产合适的微生物。
- 专利标题： Cephalosporins, processes for their preparation and microorganisms capable of their production
- 专利标题（中）： 头孢菌素类，它们的制备方法以及它们的生产合适的微生物。
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申请号： EP80303870.2申请日： 1980-10-30
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公开(公告)号： EP0028511A1公开(公告)日： 1981-05-13
- 发明人: Brown, David , Giles, Anthony Frederick , Cramer, Howard William , Noble, Hazel Mary , Nisbet, Louis Joseph , Bushell, Michael Edward , Weare, Glenis , Caldwell, Ian Yeatman
- 申请人： GLAXO GROUP LIMITED
- 申请人地址： Clarges House 6-12 Clarges Street London W1Y 8DH GB
- 专利权人： GLAXO GROUP LIMITED
- 当前专利权人： GLAXO GROUP LIMITED
- 当前专利权人地址： Clarges House 6-12 Clarges Street London W1Y 8DH GB
- 代理机构： Pett, Christopher Phineas
- 优先权： GB7937737 19791031; GB8016798 19800521
- 主分类号： C12P35/08
- IPC分类号： C12P35/08 ; C07D501/28 ; C12N1/20
摘要：
Cephamycin compounds of the formula (I)
wherein R 1 represents hydroxyl or sulphooxy and R 2 represents sulphooxy together with derivatives thereof including salts, esters, N-protected derivatives and solvates thereof are disclosed. These compounds are of great value as intermediates in the preparation of other cephamycin compounds.
The compounds of the invention may be isolated from fermentation broths of strains of the genus Streptomyces which produce the compounds and a new such strain is described. The isolation of the compounds may be achieved by a liquid/liquid or liquid/solid ion-exchange technique, and is preferably achieved by the formation of an ion-pair in a liquid/liquid technique.
wherein R 1 represents hydroxyl or sulphooxy and R 2 represents sulphooxy together with derivatives thereof including salts, esters, N-protected derivatives and solvates thereof are disclosed. These compounds are of great value as intermediates in the preparation of other cephamycin compounds.
The compounds of the invention may be isolated from fermentation broths of strains of the genus Streptomyces which produce the compounds and a new such strain is described. The isolation of the compounds may be achieved by a liquid/liquid or liquid/solid ion-exchange technique, and is preferably achieved by the formation of an ion-pair in a liquid/liquid technique.
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