发明公开
- 专利标题: Benzimidazoline derivatives, processes for their preparation and pharmaceutical compositions containing them
- 专利标题(中): 苯并咪唑衍生物,其制备方法及含有它们的药物组合物
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申请号: EP80303610申请日: 1980-10-14
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公开(公告)号: EP0028883A3公开(公告)日: 1981-06-03
- 发明人: Cantello, Barrie Christian Charles , White, Susan Mary
- 申请人: BEECHAM GROUP PLC
- 专利权人: BEECHAM GROUP PLC
- 当前专利权人: BEECHAM GROUP PLC
- 优先权: GB7938997 19791110
- 主分类号: C07D235/30
- IPC分类号: C07D235/30 ; A61K31/415
摘要:
A compound with hypoglycaemic activity having formula (II) or a pharmaceutically acceptable ammonium or acid addition salt thereof:
wherein
R' and R 2 are the same or different and represent hydrogen, Ci-6 alkyl, C 1-6 alkoxy, hydroxy or halogen; R 3 and R' are the same or different and represent hydrogen or C 1-6 alkyl; R' represents hydrogen or C 1-6 alkyl; R 6 represents C 1-6 alkyl, phenyl optionally substituted with up to 3 groups selected from halogen, C 1-6 alkyl, and C 1-6 alkoxy; or benzyl optionally substituted with up to 3 groups selected from halogen, C 1-6 alkyl and C 1-6 alkoxy; or R 5 and R 6 together represent the remaining members of a 5- or 6- membered ring optionally containing an oxygen, sulphur or additional nitrogen atom and being optionally substituted with C 1-6 alkyl, carboxy or C 1-6 alkoxycarbonyl; and R' represents phenyl, optionally substituted with up to 3 groups selected from halogen, C 1-6 alkyl and C 1-6 alkoxy, C 1-6 alkoxy carbonyl, C 1-6 alkanoyl, C 1-6 alkyanoyloxy, nitro, hydro, amino, substituted amino, and carboxy.
wherein
R' and R 2 are the same or different and represent hydrogen, Ci-6 alkyl, C 1-6 alkoxy, hydroxy or halogen; R 3 and R' are the same or different and represent hydrogen or C 1-6 alkyl; R' represents hydrogen or C 1-6 alkyl; R 6 represents C 1-6 alkyl, phenyl optionally substituted with up to 3 groups selected from halogen, C 1-6 alkyl, and C 1-6 alkoxy; or benzyl optionally substituted with up to 3 groups selected from halogen, C 1-6 alkyl and C 1-6 alkoxy; or R 5 and R 6 together represent the remaining members of a 5- or 6- membered ring optionally containing an oxygen, sulphur or additional nitrogen atom and being optionally substituted with C 1-6 alkyl, carboxy or C 1-6 alkoxycarbonyl; and R' represents phenyl, optionally substituted with up to 3 groups selected from halogen, C 1-6 alkyl and C 1-6 alkoxy, C 1-6 alkoxy carbonyl, C 1-6 alkanoyl, C 1-6 alkyanoyloxy, nitro, hydro, amino, substituted amino, and carboxy.
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