发明公开
EP0042731A1 Larvicides, insecticides, acaricides and miticides, processes for preparing them and compositions containing them
失效
杀幼虫剂,杀虫剂,杀螨剂,和杀螨剂,含有它们用于制备它们的方法和组合物。
- 专利标题: Larvicides, insecticides, acaricides and miticides, processes for preparing them and compositions containing them
- 专利标题(中): 杀幼虫剂,杀虫剂,杀螨剂,和杀螨剂,含有它们用于制备它们的方法和组合物。
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申请号: EP81302745.5申请日: 1981-06-18
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公开(公告)号: EP0042731A1公开(公告)日: 1981-12-30
- 发明人: Banks, Bernard Joseph , Leeming, Michael Raymond Graves , Penrose, Alexander Ballingall , Walshe, Nigel Derek Arthur
- 申请人: Pfizer Limited , Pfizer Corporation
- 申请人地址: Ramsgate Road Sandwich Kent CT13 9NJ GB
- 专利权人: Pfizer Limited,Pfizer Corporation
- 当前专利权人: Pfizer Limited,Pfizer Corporation
- 当前专利权人地址: Ramsgate Road Sandwich Kent CT13 9NJ GB
- 代理机构: Wood, David John
- 优先权: GB8020412 19800621
- 主分类号: C07D333/34
- IPC分类号: C07D333/34 ; C07D409/12 ; C07D417/12 ; C07D413/12 ; C07F7/08 ; A01N43/00
摘要:
Compounds of the formula:
and their alkali metal or non-toxic acid addition salts, wherein:
(a) R' is hydrogen or lower alkyl; and R 2 is lower alkyl lower alkoxy, 2,2,2-trifluoroethyl, hydroxy-lower alkyl, 2-methoxyethoxymethyl, lower alkoxycarbonyl-lower alkyl, lower alkanoyloxy-lower alkyl, aryl-lower alkyl, aryloxy-lower alkyl, thiocyanatoacetyl, lower cycloalkyl-lower alkyl, lower cycloalkyl, lower cycloalkenyl, lower alkenyl, allenyl, lower alkynyl, C 2 -C 16 alkanoyl, halo-lower alkanoyl, aryl-lower alkanoyl, N,N-di(lower alkyl)sulfamoyl, 1,2,3,4-tetrahydronaphthyl, arylthio, aryl or aroyl; or R' and R 2 together with the nitrogen atom to which they are attached form a saturated 5- or 6- membered heterocyclic group optionally containing a further heteroatom selected from 0, S and N, said N atom bearing a hydrogen atom or a lower alkyl or aryl group, said heterocyclic group optionally being substituted on a carbon atom by 1 or 2 lower alkyl groups;
(b) X is 0, S, SO or S0 2 ;
(c) Y is halogen, lower alkyl, tri(lower alkyl)silyl, lower alkoxy, or a group of the formula R 3 S- or R 3 S0 2 - wherein R 3 is lower alkyl or aryl; n is 0 or 1; and
(d) R is lower alkyl, lower alkenyl, lower cycloalkyl, allenyl, lower alkoxy-lower alkyl, aryl-lower alkyl, aryl, heteroaryl or heteroaryl-phenyl, with the proviso that when X is SO 2 , R can also be-NR 1 R 2 wherein R' and R 2 are as defined above;
the term "lower" as applied to an alkyl, alkoxy, alkanoyl, alkenyl or alkynyl group means that said group has up to 6 carbon atoms; "lower" as applied to a cycloalkyl group means that said group has from 3 to 7 carbon atoms; "lower" as applied to a cycloalkenyl group means that said group has from 4 to 7 carbon atoms;
and the term "aryl" means unsubstituted phenyl, unsubstituted naphthyl or substituted phenyl.
The compounds are insecticidal, particularly larvicidal agents, and some have acaricidal and miticidal activity. They are particularly used as blowfly larvicides on sheep and cattle.
and their alkali metal or non-toxic acid addition salts, wherein:
(a) R' is hydrogen or lower alkyl; and R 2 is lower alkyl lower alkoxy, 2,2,2-trifluoroethyl, hydroxy-lower alkyl, 2-methoxyethoxymethyl, lower alkoxycarbonyl-lower alkyl, lower alkanoyloxy-lower alkyl, aryl-lower alkyl, aryloxy-lower alkyl, thiocyanatoacetyl, lower cycloalkyl-lower alkyl, lower cycloalkyl, lower cycloalkenyl, lower alkenyl, allenyl, lower alkynyl, C 2 -C 16 alkanoyl, halo-lower alkanoyl, aryl-lower alkanoyl, N,N-di(lower alkyl)sulfamoyl, 1,2,3,4-tetrahydronaphthyl, arylthio, aryl or aroyl; or R' and R 2 together with the nitrogen atom to which they are attached form a saturated 5- or 6- membered heterocyclic group optionally containing a further heteroatom selected from 0, S and N, said N atom bearing a hydrogen atom or a lower alkyl or aryl group, said heterocyclic group optionally being substituted on a carbon atom by 1 or 2 lower alkyl groups;
(b) X is 0, S, SO or S0 2 ;
(c) Y is halogen, lower alkyl, tri(lower alkyl)silyl, lower alkoxy, or a group of the formula R 3 S- or R 3 S0 2 - wherein R 3 is lower alkyl or aryl; n is 0 or 1; and
(d) R is lower alkyl, lower alkenyl, lower cycloalkyl, allenyl, lower alkoxy-lower alkyl, aryl-lower alkyl, aryl, heteroaryl or heteroaryl-phenyl, with the proviso that when X is SO 2 , R can also be-NR 1 R 2 wherein R' and R 2 are as defined above;
the term "lower" as applied to an alkyl, alkoxy, alkanoyl, alkenyl or alkynyl group means that said group has up to 6 carbon atoms; "lower" as applied to a cycloalkyl group means that said group has from 3 to 7 carbon atoms; "lower" as applied to a cycloalkenyl group means that said group has from 4 to 7 carbon atoms;
and the term "aryl" means unsubstituted phenyl, unsubstituted naphthyl or substituted phenyl.
The compounds are insecticidal, particularly larvicidal agents, and some have acaricidal and miticidal activity. They are particularly used as blowfly larvicides on sheep and cattle.
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