发明公开
EP0043736A1 Propanolamine derivatives, their salts, processes for preparation and pharmaceutical compositions
失效
丙醇胺衍生物，它们的盐，它们的制备方法和药物制剂。
- 专利标题： Propanolamine derivatives, their salts, processes for preparation and pharmaceutical compositions
- 专利标题（中）： 丙醇胺衍生物，它们的盐，它们的制备方法和药物制剂。
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申请号： EP81303121.8申请日： 1981-07-08
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公开(公告)号： EP0043736A1公开(公告)日： 1982-01-13
- 发明人: Baxter, Andrew John Gilbey , Myers, Malcolm
- 申请人： RECKITT AND COLMAN PRODUCTS LIMITED
- 申请人地址： P.O. Box 26 1-17, Burlington Lane London W4 2RW GB
- 专利权人： RECKITT AND COLMAN PRODUCTS LIMITED
- 当前专利权人： RECKITT AND COLMAN PRODUCTS LIMITED
- 当前专利权人地址： P.O. Box 26 1-17, Burlington Lane London W4 2RW GB
- 代理机构： Allard, Susan Joyce
- 优先权： GB8022464 19810709
- 主分类号： C07C147/14
- IPC分类号： C07C147/14 ; C07C147/10 ; C07D335/06 ; C07D337/08 ; A61K31/135 ; A61K31/38
摘要：
Propanolamine derivatives of the formula:
wherein R 2 is CH 3S O or CH 3 S0 2 ; R 3 is hydrogen, methyl or methoxy; or R 2 and R 3 are together -S(O) m (CH 2 ) 4 - or -(CH 2 ) n S(O) m - (where m = 1 or 2 and n = 3 or 4); R 4 is hydrogen or alkyl C 1-4 ; Z is -(CH 2 ) 2 - or
and their non-toxic salts.
Processes for the preparation and pharmaceutical compositions thereof. The compounds exhibit both β-adrenoreceptor antagonist activity and vasodilator activity and are indicated for use in the treatment of hyperten- sion.
wherein R 2 is CH 3S O or CH 3 S0 2 ; R 3 is hydrogen, methyl or methoxy; or R 2 and R 3 are together -S(O) m (CH 2 ) 4 - or -(CH 2 ) n S(O) m - (where m = 1 or 2 and n = 3 or 4); R 4 is hydrogen or alkyl C 1-4 ; Z is -(CH 2 ) 2 - or
and their non-toxic salts.
Processes for the preparation and pharmaceutical compositions thereof. The compounds exhibit both β-adrenoreceptor antagonist activity and vasodilator activity and are indicated for use in the treatment of hyperten- sion.
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