发明公开
EP0064820A1 Substituted imidazole and imidazoline derivatives and their preparation and use
失效
Substituierte Imidazol- und Imidazolinderivate，deren Herstellung und Anwendung。
- 专利标题： Substituted imidazole and imidazoline derivatives and their preparation and use
- 专利标题（中）： Substituierte Imidazol- und Imidazolinderivate，deren Herstellung und Anwendung。
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申请号： EP82301971.6申请日： 1982-04-16
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公开(公告)号： EP0064820A1公开(公告)日： 1982-11-17
- 发明人: Karjalainen, Arto Johannes , Kurkela, Kauko Oiva Antero
- 申请人： Farmos-Yhtyma Oy
- 申请人地址： P.O. Box 425 SF-20101 Turku 10 FI
- 专利权人： Farmos-Yhtyma Oy
- 当前专利权人： Farmos-Yhtyma Oy
- 当前专利权人地址： P.O. Box 425 SF-20101 Turku 10 FI
- 代理机构： Collier, Jeremy Austin Grey (GB)
- 优先权： GB8112506 19810422
- 主分类号： C07D233/56
- IPC分类号： C07D233/56 ; C07D233/58 ; C07D233/06 ; C07D233/08 ; A61K31/415
摘要：
The invention provides novel compounds of the formu- ' la:
wherein each of R 1 , R 2 and R 3 , which can be the same or different, is hydrogen, chloro, bromo, fluoro, methyl, ethyl, methoxy, amino, hydroxy or nitro; R 4 and R 5 , which can be the same or different, are hydrogen, an alkyl radical of 1 to 7 carbon atoms, hydroxymethyl or
R 6 is hydrogen, an alkyl radical of 1 to 7 carbon atoms or
R 7 and R 8 are hydrogen, chloro or methyl; X is-CH=CH- or CHR 9 ; Rg is hydrogen or hydroxy; n is 0-7 and m is 0-6; and their non-toxic pharmaceutically acceptable acid addition salts and mixtures thereof. Processes for the preparation of these compounds are described, as are novel pharmaceutical compositions comprising at least one of the compounds and their salts. The compounds and their non-toxic salts exhibit valuable pharmacological activity and are useful in the treatment of mammals, especially as antihypertensives and also as antithrombotic and antimycotic agents.
wherein each of R 1 , R 2 and R 3 , which can be the same or different, is hydrogen, chloro, bromo, fluoro, methyl, ethyl, methoxy, amino, hydroxy or nitro; R 4 and R 5 , which can be the same or different, are hydrogen, an alkyl radical of 1 to 7 carbon atoms, hydroxymethyl or
R 6 is hydrogen, an alkyl radical of 1 to 7 carbon atoms or
R 7 and R 8 are hydrogen, chloro or methyl; X is-CH=CH- or CHR 9 ; Rg is hydrogen or hydroxy; n is 0-7 and m is 0-6; and their non-toxic pharmaceutically acceptable acid addition salts and mixtures thereof. Processes for the preparation of these compounds are described, as are novel pharmaceutical compositions comprising at least one of the compounds and their salts. The compounds and their non-toxic salts exhibit valuable pharmacological activity and are useful in the treatment of mammals, especially as antihypertensives and also as antithrombotic and antimycotic agents.
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