发明公开
EP0066242A1 Tocopheryl ester of 5-substituted picolinic acid, process for its production, and pharmaceutical composition containing it
失效
5-取代的吡啶甲酸，处理其制备方法和含有药物组合物的α-生育酚酯。
- 专利标题： Tocopheryl ester of 5-substituted picolinic acid, process for its production, and pharmaceutical composition containing it
- 专利标题（中）： 5-取代的吡啶甲酸，处理其制备方法和含有药物组合物的α-生育酚酯。
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申请号： EP82104565.5申请日： 1982-05-25
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公开(公告)号： EP0066242A1公开(公告)日： 1982-12-08
- 发明人: Yano, Mitsuo , Yoshizawa, Junji , Ishikawa, Kiyofumi , Harada, Nobuo , Matsumoto, Ikuo
- 申请人： BANYU PHARMACEUTICAL CO., LTD.
- 申请人地址： 7-8, Nihonbashi Honcho 2-chome Chuo-ku Tokyo 103 JP
- 专利权人： BANYU PHARMACEUTICAL CO., LTD.
- 当前专利权人： BANYU PHARMACEUTICAL CO., LTD.
- 当前专利权人地址： 7-8, Nihonbashi Honcho 2-chome Chuo-ku Tokyo 103 JP
- 代理机构： Kraus, Walter, Dr.
- 优先权： JP78702/81 19810526; JP60359/82 19820413
- 主分类号： C07D405/12
- IPC分类号： C07D405/12 ; A61K31/44
摘要：
An a-tocopheryl 5-substituted picolinate of the formula
wherein R represents an alkyl group which may have a substituent, a lower alkenyl group, a phenyl(lower alkyl) group, or a phenyl group which may have a substituent, and Q represents a methylene group or an oxygen or sulfur atom, or a pharmaceutically acceptable acid addition salt thereof. This compound can be produced by reacting a substituted picolinic acid of the formula
wherein R and Q are as defined above, or its reactive derivative with a-tocopherol of the formula
and as required, contacting the resulting compound with a pharmaceutically acceptable acid. A pharmaceutical composition comprising said compound as an active ingredient is useful for the treatment of hypertension.
wherein R represents an alkyl group which may have a substituent, a lower alkenyl group, a phenyl(lower alkyl) group, or a phenyl group which may have a substituent, and Q represents a methylene group or an oxygen or sulfur atom, or a pharmaceutically acceptable acid addition salt thereof. This compound can be produced by reacting a substituted picolinic acid of the formula
wherein R and Q are as defined above, or its reactive derivative with a-tocopherol of the formula
and as required, contacting the resulting compound with a pharmaceutically acceptable acid. A pharmaceutical composition comprising said compound as an active ingredient is useful for the treatment of hypertension.
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