发明公开
EP0074820A1 Substituted pyrimid-2-ones, the salts thereof, processes for their preparation and pharmaceutical compositions containing them
失效
取代的嘧啶-2-酮，它们的盐，它们的制备方法和含有它们的药物组合物。
- 专利标题： Substituted pyrimid-2-ones, the salts thereof, processes for their preparation and pharmaceutical compositions containing them
- 专利标题（中）： 取代的嘧啶-2-酮，它们的盐，它们的制备方法和含有它们的药物组合物。
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申请号： EP82304780.8申请日： 1982-09-10
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公开(公告)号： EP0074820A1公开(公告)日： 1983-03-23
- 发明人: Benneche, Tore , Gacek, Mikkel Josef , Undheim, Kjell
- 申请人： NYEGAARD & CO. A/S
- 申请人地址： Nycoveien 2 Postboks 4220 Oslo 4 NO
- 专利权人： NYEGAARD & CO. A/S
- 当前专利权人： NYEGAARD & CO. A/S
- 当前专利权人地址： Nycoveien 2 Postboks 4220 Oslo 4 NO
- 代理机构： Cockbain, Julian, Dr.
- 优先权： GB8127505 19810911
- 主分类号： C07D239/36
- IPC分类号： C07D239/36 ; A61K31/505
摘要：
Compounds of general formula:
(wherein X represents a halogen atom or a trifluoromethyl group; R 1 and R 2 , which may be the same or different, each represents a hydrogen atom, or a C 1-4 alkyl group, and R 3 represents a hydrogen atom or a C 1-5 saturated or unsaturated, straight or branched acyclic aliphatic group; a C34 saturated or unsaturated cyclic aliphatic group; a heterocyclic substituted aliphatic group; an araliphatic group; or a heterocyclic or carbocyclic aryl group; any of said groups optionally carrying one or more substituents selected from halogen, oxo, hydroxy, mercapto, C 1-4 alkyl, C 1-4 alkoxy, C 1-4 alkanoyloxy and amino) and, where an acidic or basic group is present, physiologically compatible salts thereof have been found to be of use in combating abnormal cell proliferation.
The compounds of formula I may be prepared by reaction of a 5-halo- or 5-trifluoromethyl-pyrimidin-2-one with an appropriate isocyanate.
(wherein X represents a halogen atom or a trifluoromethyl group; R 1 and R 2 , which may be the same or different, each represents a hydrogen atom, or a C 1-4 alkyl group, and R 3 represents a hydrogen atom or a C 1-5 saturated or unsaturated, straight or branched acyclic aliphatic group; a C34 saturated or unsaturated cyclic aliphatic group; a heterocyclic substituted aliphatic group; an araliphatic group; or a heterocyclic or carbocyclic aryl group; any of said groups optionally carrying one or more substituents selected from halogen, oxo, hydroxy, mercapto, C 1-4 alkyl, C 1-4 alkoxy, C 1-4 alkanoyloxy and amino) and, where an acidic or basic group is present, physiologically compatible salts thereof have been found to be of use in combating abnormal cell proliferation.
The compounds of formula I may be prepared by reaction of a 5-halo- or 5-trifluoromethyl-pyrimidin-2-one with an appropriate isocyanate.
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