发明公开
EP0080220A1 Dihydropyridines, methods for their production and their formulation and use as pharmaceuticals
失效
二氢吡啶，它们的制备方法，其组合物和它们作为药物的用途。
- 专利标题： Dihydropyridines, methods for their production and their formulation and use as pharmaceuticals
- 专利标题（中）： 二氢吡啶，它们的制备方法，其组合物和它们作为药物的用途。
-
申请号： EP82201367.8申请日： 1982-11-01
-
公开(公告)号： EP0080220A1公开(公告)日： 1983-06-01
- 发明人: Dixon, John , Tinker, Alan Charles
- 申请人： FISONS plc
- 申请人地址： Fison House Princes Street Ipswich Suffolk IP1 1QH GB
- 专利权人： FISONS plc
- 当前专利权人： FISONS plc
- 当前专利权人地址： Fison House Princes Street Ipswich Suffolk IP1 1QH GB
- 代理机构： Craig, Christopher Bradberry
- 优先权： GB8134550 19811117; GB8224923 19820901
- 主分类号： C07D413/04
- IPC分类号： C07D413/04 ; C07D417/04 ; C07D491/04 ; A61K31/445
摘要：
There are described compounds of formula
in which X is oxygen or sulphur,
R 1 and R 2 , which may be the same or different, each represent alkyl C 1 to 6, -(CH 2 ) n OR 5 , or -(CH 2 ) n NR 6 R 7 , and in addition R 2 may represent hydrogen,
n is a whole number from 2 to 4 inclusive,
R 3 represents -CH 2 0H, -CN, -CH(OR 4 ) 2 , -CHO, -CH=NOH, -CF 3 , or, together with R 2 forms a chain -CHOH-,
R 4 represents alkyl C 1 to 6,
R s represents alkyl C 1 to 6 or phenyl,
R 6 and R 7 , which may be the same or different, each represent alkyl C 1 to 6 optionally substituted by phenyl, and
R 8 is alkyl C 1 to 6,
and pharmaceutically acceptable acid addition salts of those compounds containing a basic nitrogen atom.
There are also described methods for making the compounds and pharmaceutical, e.g. cardiac, compositions containing them.
in which X is oxygen or sulphur,
R 1 and R 2 , which may be the same or different, each represent alkyl C 1 to 6, -(CH 2 ) n OR 5 , or -(CH 2 ) n NR 6 R 7 , and in addition R 2 may represent hydrogen,
n is a whole number from 2 to 4 inclusive,
R 3 represents -CH 2 0H, -CN, -CH(OR 4 ) 2 , -CHO, -CH=NOH, -CF 3 , or, together with R 2 forms a chain -CHOH-,
R 4 represents alkyl C 1 to 6,
R s represents alkyl C 1 to 6 or phenyl,
R 6 and R 7 , which may be the same or different, each represent alkyl C 1 to 6 optionally substituted by phenyl, and
R 8 is alkyl C 1 to 6,
and pharmaceutically acceptable acid addition salts of those compounds containing a basic nitrogen atom.
There are also described methods for making the compounds and pharmaceutical, e.g. cardiac, compositions containing them.
公开/授权文献
信息查询
