发明公开
- 专利标题： Pharmaceutical composition
- 专利标题（中）： 药物组合物
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申请号： EP83302290申请日： 1983-04-22
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公开(公告)号： EP0093551A3公开(公告)日： 1985-11-21
- 发明人: Toyoshima, Shigeshi , Fukushima , Seto, Yoshiko , Kumashiro, Izumi
- 申请人： AJINOMOTO CO., INC.
- 专利权人： AJINOMOTO CO., INC.
- 当前专利权人： AJINOMOTO CO., INC.
- 优先权： JP7330682 19820430; JP6599983 19830414
- 主分类号： A61K45/06
- IPC分类号： A61K45/06 ; A61K37/26 ; C07C125/065 ; C07C103/46 ; C07C103/52 ; A61K31/27 ; A61K31/195 ; A61K31/165
摘要：
Phenylalinine derivatives having the general formula:
and their non-toxic salts, have been found to promote the absorption of medicinal substances such as insulin. In the above formula, R' is a hydrogen atom, a fluorine atom, a nitro group, a hydroxyl group or a hydroxyl group protected by an esterifying group, X is -CO- or -SO 2 -, -Y- is a straight bond, a lower alkylene group, a substituted or unsubstituted vinylene group, or a group having the form- fula -CH 2 -O- or -0-CH 2 -, and R 2 is a substituted or unsubstituted phenyl or naphthyl group; or the group R 2 -Y-CO- is an N-benzyloxy-carbonylphenylalanyl group, an N-benzyloxycarbonyl-4-flurophenylalanyl group or an N-(m-methoxycinnamoyl)phenylalanyl group.
and their non-toxic salts, have been found to promote the absorption of medicinal substances such as insulin. In the above formula, R' is a hydrogen atom, a fluorine atom, a nitro group, a hydroxyl group or a hydroxyl group protected by an esterifying group, X is -CO- or -SO 2 -, -Y- is a straight bond, a lower alkylene group, a substituted or unsubstituted vinylene group, or a group having the form- fula -CH 2 -O- or -0-CH 2 -, and R 2 is a substituted or unsubstituted phenyl or naphthyl group; or the group R 2 -Y-CO- is an N-benzyloxy-carbonylphenylalanyl group, an N-benzyloxycarbonyl-4-flurophenylalanyl group or an N-(m-methoxycinnamoyl)phenylalanyl group.
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