发明公开
- 专利标题: 1,4-Dihydropyridine derivatives
- 专利标题(中): 1,4-二氢吡啶衍生物
-
申请号: EP83104076申请日: 1983-04-26
-
公开(公告)号: EP0093945A3公开(公告)日: 1984-09-12
- 发明人: Watanabe, Minoru , Moto, Kenji , Takemoto, Yoshinori , Hatta, Takao , Hashimoto, Tamotsu , Yamada, Koji
- 申请人: KYOWA HAKKO KOGYO CO., LTD.
- 专利权人: KYOWA HAKKO KOGYO CO., LTD.
- 当前专利权人: KYOWA HAKKO KOGYO CO., LTD.
- 优先权: JP7142582 19820430
- 主分类号: C07D211/94
- IPC分类号: C07D211/94 ; C07D405/12 ; C07D409/12 ; C07D401/12 ; A61K31/445
摘要:
Compounds having effects to dilate coronary artery and peripheral blood vessels and to depress the blood pressure, and useful as drugs for cardiovascular disease are represented by the following general formula:
wherein R, represents a hydrogen atom, an alkyl group having 1-5 carbon atoms, an alkenyl group having 2-5 carbon atoms, an aralkyl group having 7-13 carbon atoms or an acyl group having 1-7 carbon atoms, R. and R 3 are the same or different groups and each represents a substituted or unsubstituted alkyl group having 1-5 carbon atoms, an alkenyl group having 2-5 carbon atoms, a disubstituted aminoalkyl group having 1-5 carbon atoms or a substituted or unsubstituted heterocyclic group, R 4 and R 5 are the same or different groups and each represents a hydrogen atom, a halogen atom or a nitro group, and R 6 and R 7 are the same or different groups and each represents an alkyl group having 1-5 carbon atoms; the pharmaceutically acceptable acid addition salt thereof are also effective therapeutic compounds.
wherein R, represents a hydrogen atom, an alkyl group having 1-5 carbon atoms, an alkenyl group having 2-5 carbon atoms, an aralkyl group having 7-13 carbon atoms or an acyl group having 1-7 carbon atoms, R. and R 3 are the same or different groups and each represents a substituted or unsubstituted alkyl group having 1-5 carbon atoms, an alkenyl group having 2-5 carbon atoms, a disubstituted aminoalkyl group having 1-5 carbon atoms or a substituted or unsubstituted heterocyclic group, R 4 and R 5 are the same or different groups and each represents a hydrogen atom, a halogen atom or a nitro group, and R 6 and R 7 are the same or different groups and each represents an alkyl group having 1-5 carbon atoms; the pharmaceutically acceptable acid addition salt thereof are also effective therapeutic compounds.
信息查询