发明公开
EP0096586A2 Temperature sensitive multicopy plasmids and organisms containing the same, their production and use in protein production
失效
包含相同和生物体,它们的制备和使用用于蛋白质生产热敏多拷贝质粒。
- 专利标题: Temperature sensitive multicopy plasmids and organisms containing the same, their production and use in protein production
- 专利标题(中): 包含相同和生物体,它们的制备和使用用于蛋白质生产热敏多拷贝质粒。
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申请号: EP83303293.1申请日: 1983-06-07
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公开(公告)号: EP0096586A2公开(公告)日: 1983-12-21
- 发明人: Gelfand, David Harow , Strange, Carolyn Jan , Watson, Robert Malcolm
- 申请人: CETUS CORPORATION
- 申请人地址: 1400 Fifty-Third Street Emeryville California 94608 US
- 专利权人: CETUS CORPORATION
- 当前专利权人: CETUS CORPORATION
- 当前专利权人地址: 1400 Fifty-Third Street Emeryville California 94608 US
- 代理机构: Bizley, Richard Edward
- 优先权: US386348 19820608
- 主分类号: C12N15/63
- IPC分类号: C12N15/63 ; C12N1/20 ; C12P21/00
摘要:
The invention provides plasmids of ColEl type parentage which have a temperature sensitive replication system such that the plasmid copy number in a given host cell may be controlled by a temperature shift. Such plasmids permit the use of temperature as a switch for controlling gene amplification and hence the production of corresponding protein in a host cell.
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