发明公开
EP0130862A1 N-methanesulfonic acid derivatives of 3-demethoxy-istamycin B and production thereof
失效
N-Methansulfonsäure-Derivate von 3-Demethoxyistamycin-B und ihre Herstellung。
- 专利标题： N-methanesulfonic acid derivatives of 3-demethoxy-istamycin B and production thereof
- 专利标题（中）： N-Methansulfonsäure-Derivate von 3-Demethoxyistamycin-B und ihre Herstellung。
-
申请号： EP84401075.1申请日： 1984-05-24
-
公开(公告)号： EP0130862A1公开(公告)日： 1985-01-09
- 发明人: Umezawa, Hamao , Kondo, Shinichi
- 申请人： ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI
- 申请人地址： 14-23, Kami Osaki 3-chome Shinagawa-ku, Tokyo 141 JP
- 专利权人： ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI
- 当前专利权人： ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI
- 当前专利权人地址： 14-23, Kami Osaki 3-chome Shinagawa-ku, Tokyo 141 JP
- 代理机构： Nony, Michel
- 优先权： JP90752/83 19830525
- 主分类号： C07H15/22
- IPC分类号： C07H15/22 ; A61K31/70
摘要：
As new semi-synthetic antibiotic derivatives are provided N-methanesulfonic acid derivatives of 3-demethoxyistamycin B which are less toxic than the parent 3-demethoxyistamycin B but retain usefully high antibacterial activity of the parent antibiotic. The new derivatives are produced by a method of N-sulfomethylation where 3-demethoxyistamycin B is reacted with an aldehyde such as paraformaldehyde and sulfurous acid or sulfite reagent.
公开/授权文献
信息查询
