发明公开
EP0135159A2 Monoclonal antibody having specificity for the double-stranded conformation of native DNA and diagnostic methods using same
失效
特异性针对天然DNA的双链结构及其在诊断方法中使用的单克隆抗体。
- 专利标题： Monoclonal antibody having specificity for the double-stranded conformation of native DNA and diagnostic methods using same
- 专利标题（中）： 特异性针对天然DNA的双链结构及其在诊断方法中使用的单克隆抗体。
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申请号： EP84109813.0申请日： 1984-08-17
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公开(公告)号： EP0135159A2公开(公告)日： 1985-03-27
- 发明人: Huang, Chun-Ming , Cohen, Stanley Norman
- 申请人： CETUS CORPORATION
- 申请人地址： 1400 Fifty-Third Street Emeryville California 94608 US
- 专利权人： CETUS CORPORATION
- 当前专利权人： CETUS CORPORATION
- 当前专利权人地址： 1400 Fifty-Third Street Emeryville California 94608 US
- 代理机构： VOSSIUS & PARTNER
- 优先权： US524596 19830819
- 主分类号： C12P21/00
- IPC分类号： C12P21/00 ; C12N5/00 ; G01N33/577 ; C12Q1/68 ; C12N15/00 ; C07H21/04 ; C12P19/34
摘要：
Described are monoclonal antibodies having conformation-dependent specificity for native dsDNA, as exemplified by the IgM antibody produced by murine hybridoma ATCC No. HB 8329, have been prepared. These antibodies may be bound to double-stranded DNA to form immune complexes and thus are useful in immunodiagnostic tests to detect DNA duplex formation by DNA hybridization and to separate dsDNA from a solution containing it.
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