发明公开
EP0136788A1 Process for preparing penicillin and cephalosporin sulfones
失效
Verfahren zur Herstellung von青霉素和头孢菌素磺隆。
- 专利标题： Process for preparing penicillin and cephalosporin sulfones
- 专利标题（中）： Verfahren zur Herstellung von青霉素和头孢菌素磺隆。
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申请号： EP84305359.6申请日： 1984-08-07
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公开(公告)号： EP0136788A1公开(公告)日： 1985-04-10
- 发明人: Hatfield, Lowell Deloss
- 申请人： ELI LILLY AND COMPANY
- 申请人地址： 307, East McCarty Street Indianapolis Indiana 46285 US
- 专利权人： ELI LILLY AND COMPANY
- 当前专利权人： ELI LILLY AND COMPANY
- 当前专利权人地址： 307, East McCarty Street Indianapolis Indiana 46285 US
- 代理机构： Hudson, Christopher Mark
- 优先权： US521197 19830808
- 主分类号： C07D499/04
- IPC分类号： C07D499/04 ; C07D501/04 ; C07D499/44 ; C07D501/20
摘要：
There is disclosed a process for preparing a penicillin or cephalosporin sulfone of the formula
wherein:
R' is hydrogen or a carboxylic acid acyl residue;
R 2 is hydrogen or lower alkoxy;
R 3 is hydrogen, a carboxy protecting group or a salt forming group;
A is
in which:
R 4 is halo, lower alkyl, lower alkoxy, or -CH 2 R 6 , wherein R 6 is lower alkanoyloxy or a heterocyclic group; and
R 5 is hydrogen or alkoxycarbonyloxy; comprising reacting a compound of the formula
with an oxidizing agent and a catalytic amount of ruthenium tetroxide.
wherein:
R' is hydrogen or a carboxylic acid acyl residue;
R 2 is hydrogen or lower alkoxy;
R 3 is hydrogen, a carboxy protecting group or a salt forming group;
A is
in which:
R 4 is halo, lower alkyl, lower alkoxy, or -CH 2 R 6 , wherein R 6 is lower alkanoyloxy or a heterocyclic group; and
R 5 is hydrogen or alkoxycarbonyloxy; comprising reacting a compound of the formula
with an oxidizing agent and a catalytic amount of ruthenium tetroxide.
公开/授权文献
- EP0136788B1 Process for preparing penicillin and cephalosporin sulfones 公开/授权日：1988-12-07
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