发明公开
EP0138616A2 Nona- and dodecapeptides for augmenting natural killer cell activity, processes for making them and pharmaceutical compositions comprising them
失效
九 - 和具有增强的细胞杀伤活性十肽，它们的制备方法和它们的药物组合物。
- 专利标题： Nona- and dodecapeptides for augmenting natural killer cell activity, processes for making them and pharmaceutical compositions comprising them
- 专利标题（中）： 九 - 和具有增强的细胞杀伤活性十肽，它们的制备方法和它们的药物组合物。
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申请号： EP84307090.5申请日： 1984-10-16
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公开(公告)号： EP0138616A2公开(公告)日： 1985-04-24
- 发明人: Nestor, John J. , Moffatt, John G. , Sims, John M.
- 申请人： SYNTEX (U.S.A.) INC.
- 申请人地址： 3401 Hillview Avenue Palo Alto California 94303 US
- 专利权人： SYNTEX (U.S.A.) INC.
- 当前专利权人： SYNTEX (U.S.A.) INC.
- 当前专利权人地址： 3401 Hillview Avenue Palo Alto California 94303 US
- 代理机构： Armitage, Ian Michael
- 优先权： US542632 19831017
- 主分类号： C07K7/06
- IPC分类号： C07K7/06 ; C07K7/08 ; A61K37/02 ; C12N15/00
摘要：
Nonapeptides and dodecapeptides of the formula
wherein X is N-acyl-(1-6C)-Gln, or N-acyl-11-6C)-Cys-Tyr-Cys-Gln- or pyro-glutamic acid and Y is Gly, Glu, GlyN(R) 2 or Glu-N(R) 2 wherein R is hydrogen or alkyl of 1 to 6 carbon atoms and the pharmaceutically acceptable, nontoxic salts thereof, which augment natural killer cell activity.
wherein X is N-acyl-(1-6C)-Gln, or N-acyl-11-6C)-Cys-Tyr-Cys-Gln- or pyro-glutamic acid and Y is Gly, Glu, GlyN(R) 2 or Glu-N(R) 2 wherein R is hydrogen or alkyl of 1 to 6 carbon atoms and the pharmaceutically acceptable, nontoxic salts thereof, which augment natural killer cell activity.
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