发明公开
EP0141613A2 A process for producing an optically active 3-(3,4-dihydroxphenyl) serine and a proteced derivative thereof
失效
一种制备光学活性的3-（3,4-二羟基苯基）过程-Serins及其保护的衍生物。
- 专利标题： A process for producing an optically active 3-(3,4-dihydroxphenyl) serine and a proteced derivative thereof
- 专利标题（中）： 一种制备光学活性的3-（3,4-二羟基苯基）过程-Serins及其保护的衍生物。
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申请号： EP84307297.6申请日： 1984-10-24
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公开(公告)号： EP0141613A2公开(公告)日： 1985-05-15
- 发明人: Umezawa, Hamao , Takeuchi, Tomio , Nagatsu, Toshiharu , Hamada, Masa , Iwadare, Shuichi , Matsumoto, Ikuo , Morishima, Hajime
- 申请人： ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI , BANYU PHARMACEUTICAL CO., LTD.
- 申请人地址： 14-23, Kami Osaki 3-chome Shinagawa-ku, Tokyo 141 JP
- 专利权人： ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI,BANYU PHARMACEUTICAL CO., LTD.
- 当前专利权人： ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI,BANYU PHARMACEUTICAL CO., LTD.
- 当前专利权人地址： 14-23, Kami Osaki 3-chome Shinagawa-ku, Tokyo 141 JP
- 代理机构： Pendlebury, Anthony
- 优先权： JP205859/83 19831104
- 主分类号： C12P13/04
- IPC分类号： C12P13/04 ; C12P41/00
摘要：
N-acyl-DL-3-(3,4-dihydroxyphenyl)serine or a catecholic hydroxyl-protected derivative thereof is stereospecifically de-acylated by reaction with a microorganism of Streptomyces or Streptoverticillium having an acylase or with an extract of said microorganism containing said acylase, to produce L-3-(3,4-dihydroxyphenyl)serine or the hydroxyl-protected derivative thereof, with the N-acyl-D-3-(3,4-dihydroxyphenyl)serine compound remaining unaltered. The L-3-(3,4-dihydroxyphenyl)-serine compound so produced can be separated from the N-acyl-D-3-(3,4-dihydroxyphenyl)serine compound owing to its different properties.
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