发明授权
EP0141684B1 17-oxo-21-thioesters d'hydrocortisone, leur préparation et leurs applications comme médicament
失效
盐酸酯-17-羧酸酯21-硫代羧酸酯，其制备及其用作药物
- 专利标题： 17-oxo-21-thioesters d'hydrocortisone, leur préparation et leurs applications comme médicament
- 专利标题（英）： Hydrocortisone-17-carboxylic-acid ester 21-thiocarboxylyc-acid esters, their preparation and their use as medicines
- 专利标题（中）： 盐酸酯-17-羧酸酯21-硫代羧酸酯，其制备及其用作药物
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申请号： EP84401553.7申请日： 1984-07-24
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公开(公告)号： EP0141684B1公开(公告)日： 1987-09-30
- 发明人: Aubard, Gilbert Gustave , Grouhel, Agnès Geneviève , Junien, Jean-Louis , Roux, Claude Paul Joseph , Torossian, Diéran Robert
- 申请人： JOUVEINAL S.A.
- 申请人地址： Tour Maine Montparnasse 33 Avenue du Maine F-75755 Paris Cedex 15 FR
- 专利权人： JOUVEINAL S.A.
- 当前专利权人： JOUVEINAL S.A.
- 当前专利权人地址： Tour Maine Montparnasse 33 Avenue du Maine F-75755 Paris Cedex 15 FR
- 代理机构： Bourgognon, Jean-Marie
- 优先权： FR8313777 19830826
- 主分类号： C07J31/00
- IPC分类号： C07J31/00 ; A61K31/57
摘要：
1. Claims (for the Contracting States : BE, CH, DE, GB, IT, LI, LU, NL, SE) 3,20-dione 11 beta-hydroxy-pregn-4-ene S-21 thioacetate-17-butyrate. 1. Claims (for the Contracting State : AT) Process for the preparation of 3,20-dione 11 beta-hydroxy-pregn-4-ene S-21-thioacetate-17-butyrate and 3,20-dione 11 beta-hydroxy-pregn-4-ene S-21-thiopropionate-17-butyrate, characterized in that it comprises reacting a 21-sulphonate steroid of formula : see diagramm : EP0141684,P9,F2 in which R is a lower alkyl with an alkali metal thiocarboxylate of formula : M-S-CO-R1 in which M is an alkali metal atom and R1 methyl or ethyl.
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