发明公开
EP0150688A1 Salts of L-carnitine and alkanoyl L-carnitines and process for preparing same
失效
L-肉碱和链烷酰基L-肉碱的盐以及制备方法相同的方法。
- 专利标题： Salts of L-carnitine and alkanoyl L-carnitines and process for preparing same
- 专利标题（中）： L-肉碱和链烷酰基L-肉碱的盐以及制备方法相同的方法。
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申请号： EP84830329.3申请日： 1984-12-05
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公开(公告)号： EP0150688A1公开(公告)日： 1985-08-07
- 发明人: Cavazza, Claudio
- 申请人： Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
- 申请人地址： Viale Shakespeare, 47 I-00144 Roma IT
- 专利权人： Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
- 当前专利权人： Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
- 当前专利权人地址： Viale Shakespeare, 47 I-00144 Roma IT
- 代理机构： Fassi, Aldo, Dr.
- 优先权： IT4959483 19831228; IT4912384 19841106
- 主分类号： C07C101/30
- IPC分类号： C07C101/30 ; A61K31/195
摘要：
Novel L-carnitine and alkanoyl L-carnitine salts and a process for their preparation are disclosed. The salts have general formula
wherein
X- ist an anion selected among acid aspartate, acid citrate, acid phosphate, acid fumarate, lactate, acid maleate, acid oxalate, acid sulphate and orotate;
R is hydrogen provided that X- is other than orotate, or lower alkanoyl selected among acetyl, propionyl and butyryl; and
n is ½ if X - is orotate, and 1 if X- is one of the other anions.
Since they are not hygroscopic, these salts can be easily compounded and are favourably suitable for manufacturing solid administration forms. Their aqueous solutions are less acid than those of the corresponding chlorides: consequently, these salts are also suitable for manufacturing injectable administration forms.
wherein
X- ist an anion selected among acid aspartate, acid citrate, acid phosphate, acid fumarate, lactate, acid maleate, acid oxalate, acid sulphate and orotate;
R is hydrogen provided that X- is other than orotate, or lower alkanoyl selected among acetyl, propionyl and butyryl; and
n is ½ if X - is orotate, and 1 if X- is one of the other anions.
Since they are not hygroscopic, these salts can be easily compounded and are favourably suitable for manufacturing solid administration forms. Their aqueous solutions are less acid than those of the corresponding chlorides: consequently, these salts are also suitable for manufacturing injectable administration forms.
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