发明公开
EP0156524A3 2'-Chloropentostatin, a pharmaceutical composition comprising the compound and a novel microorganism for producing the compound
失效
2'-氯同系物，包含化合物的药物组合物和用于生产化合物的新型微生物
- 专利标题： 2'-Chloropentostatin, a pharmaceutical composition comprising the compound and a novel microorganism for producing the compound
- 专利标题（中）： 2'-氯同系物，包含化合物的药物组合物和用于生产化合物的新型微生物
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申请号： EP85301310申请日： 1985-02-27
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公开(公告)号： EP0156524A3公开(公告)日： 1986-04-16
- 发明人: Schaumberg, John P. , French, James C. , Underhill, Marjorie A. , Hokanson, Gerard C. , Tunac, Josefino B.
- 申请人： WARNER-LAMBERT COMPANY
- 专利权人： WARNER-LAMBERT COMPANY
- 当前专利权人： WARNER-LAMBERT COMPANY
- 优先权： US590239 19840316
- 主分类号： C07H19/052
- IPC分类号： C07H19/052 ; A61K31/70 ; C12P19/38 ; C12R01/04
摘要：
The compound 2'-chloropentostatin, which has the formula
is a potent inhibitor of the enzyme adenosine deaminase and possesses utility as an agent for potentiating the activity of antiviral agents for the treatment of DNA viruses which agents contain an adenine moiety, such as 9-(beta-D-arabi- nofuranosyl) adenine. A pure strain of actinomycete, designated ATCC 38365 which is capable of producing 2'-chloropentostatin, a method of producing 2'-chloropentostatin by aerobic fermentation, and pharmaceutical compositions including 2'-chloropentostatin are also disclosed.
is a potent inhibitor of the enzyme adenosine deaminase and possesses utility as an agent for potentiating the activity of antiviral agents for the treatment of DNA viruses which agents contain an adenine moiety, such as 9-(beta-D-arabi- nofuranosyl) adenine. A pure strain of actinomycete, designated ATCC 38365 which is capable of producing 2'-chloropentostatin, a method of producing 2'-chloropentostatin by aerobic fermentation, and pharmaceutical compositions including 2'-chloropentostatin are also disclosed.
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