发明公开
- 专利标题： 4-(5H-Dibenzo[a,d]cyclohepten-5-yl) piperidine compounds
- 专利标题（中）： 4-（5H-二苯并咪唑，叔丁氧羰基-5-基）哌啶化合物
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申请号： EP85103884申请日： 1985-04-01
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公开(公告)号： EP0157399A3公开(公告)日： 1986-02-05
- 发明人: Young, Steven D.
- 申请人： MERCK & CO. INC.
- 专利权人： MERCK & CO. INC.
- 当前专利权人： MERCK & CO. INC.
- 优先权： US596958 19840405
- 主分类号： C07D211/14
- IPC分类号： C07D211/14 ; C07D211/16 ; C07D211/18 ; C07D211/96 ; C07D401/04 ; C07D487/04 ; A61K31/445 ; C07D241/00 ; C07D235/00
摘要：
Novel 4-(5H-dibenzo[a,d]cyclohepten-5-yl)-piperidine compounds of the formula:
are disclosed wherein the bond designation between the 10 and 11 positions indicates that the bond may be a saturated single bond or an unsaturated double bond,
X is hydrogen, halogen, trifluoromethyl or lower alkoxy; R is, e.g., selected from the group consisting of:
a) a substituted aralkyl group represented by the formula:
wherein A is di(lower alkyl)amino or lower alkoxy; b) an aralkenyl group represented by the formula:
where D is lower alkoxy; c) a nitrogen containing alkyl group represented by the formula:
wherein Y is -CN,
or
d) an acyl group represented by the formula:
wherein R' is lower alkyl, substituted lower alkyl, phenyl or substituted phenyl, styryl or substituted styryl; and acid addition salts thereof. The compounds have the property of inhibiting calcium induced contraction of the smooth muscle.
are disclosed wherein the bond designation between the 10 and 11 positions indicates that the bond may be a saturated single bond or an unsaturated double bond,
X is hydrogen, halogen, trifluoromethyl or lower alkoxy; R is, e.g., selected from the group consisting of:
a) a substituted aralkyl group represented by the formula:
wherein A is di(lower alkyl)amino or lower alkoxy; b) an aralkenyl group represented by the formula:
where D is lower alkoxy; c) a nitrogen containing alkyl group represented by the formula:
wherein Y is -CN,
or
d) an acyl group represented by the formula:
wherein R' is lower alkyl, substituted lower alkyl, phenyl or substituted phenyl, styryl or substituted styryl; and acid addition salts thereof. The compounds have the property of inhibiting calcium induced contraction of the smooth muscle.
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