发明公开
EP0174071A2 Dihydropyridine derivatives and their production, formulation and use as pharmaceuticals
失效
Dihydropyridinderivate和ihre Herstellung，Formulierung und Verwendung als Pharmazeutika。
- 专利标题： Dihydropyridine derivatives and their production, formulation and use as pharmaceuticals
- 专利标题（中）： Dihydropyridinderivate和ihre Herstellung，Formulierung und Verwendung als Pharmazeutika。
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申请号： EP85304805.6申请日： 1985-07-05
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公开(公告)号： EP0174071A2公开(公告)日： 1986-03-12
- 发明人: Baxter, Andrew John Gilby , Dixon, John , Gould, Kenneth John , Fuher, John
- 申请人： FISONS plc
- 申请人地址： Fison House Princes Street Ipswich Suffolk IP1 1QH GB
- 专利权人： FISONS plc
- 当前专利权人： FISONS plc
- 当前专利权人地址： Fison House Princes Street Ipswich Suffolk IP1 1QH GB
- 代理机构： Craig, Christopher Bradberry
- 优先权： GB8419332 19840728
- 主分类号： C07D211/90
- IPC分类号： C07D211/90 ; A61K31/44
摘要：
There are described compounds of formula I,
in which R 2 and R 3 , which may be the same or different, each represent alkyl C1 to 6 or cycloalkyl C3 to 8,
R 7 and R 8 , which may be the same or different, each represent alkyl C1 to 6 optionally substituted by halogen, and
X, Y and Z, which may be the same or different, are each hydrogen, halogen, nitro or alkyl C1 to 6 optionally substituted by halogen, or Z is as defined above and X and Y, together with the carbon atoms to which they are attached, form a C5 to 8 carbocyclic ring, other than a benzene ring,
provided that when R 2 , R 3 , R 7 and R 8 are all methyl and X and Z are hydrogen; or when R 2 and R 3 are both ethyl, R 7 and R 8 are both methyl and X and Z are hydrogen; then Y is other I than methyl.
There are also described methods for making the compounds and their formulation and use as pharmaceuticals, e.g. for the treatment of cardiovascular conditions.
in which R 2 and R 3 , which may be the same or different, each represent alkyl C1 to 6 or cycloalkyl C3 to 8,
R 7 and R 8 , which may be the same or different, each represent alkyl C1 to 6 optionally substituted by halogen, and
X, Y and Z, which may be the same or different, are each hydrogen, halogen, nitro or alkyl C1 to 6 optionally substituted by halogen, or Z is as defined above and X and Y, together with the carbon atoms to which they are attached, form a C5 to 8 carbocyclic ring, other than a benzene ring,
provided that when R 2 , R 3 , R 7 and R 8 are all methyl and X and Z are hydrogen; or when R 2 and R 3 are both ethyl, R 7 and R 8 are both methyl and X and Z are hydrogen; then Y is other I than methyl.
There are also described methods for making the compounds and their formulation and use as pharmaceuticals, e.g. for the treatment of cardiovascular conditions.
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