发明公开
EP0182301A3 3-Substituted carbacephem and cephem compounds and pharmaceutical compositions
失效
3-取代的碳水化合物和CEPHEM化合物和药物组合物
- 专利标题： 3-Substituted carbacephem and cephem compounds and pharmaceutical compositions
- 专利标题（中）： 3-取代的碳水化合物和CEPHEM化合物和药物组合物
-
申请号： EP85114501申请日： 1985-11-14
-
公开(公告)号： EP0182301A3公开(公告)日： 1987-07-22
- 发明人: Mochida, Kenichi , Ogasa, Takehiro , Shimada, Junichi , Hirata, Tadashi , Sato, Kiyoshi , Okachi, Ryo
- 申请人： KYOWA HAKKO KOGYO CO., LTD.
- 专利权人： KYOWA HAKKO KOGYO CO., LTD.
- 当前专利权人： KYOWA HAKKO KOGYO CO., LTD.
- 优先权： JP24138084 19841115
- 主分类号： C07D501/59
- IPC分类号： C07D501/59 ; C07D471/04 ; A61K31/545 ; C07D221/00 ; C07D205/00
摘要：
Carbacephem and cephem compounds represented by the formula:
[Wherein X is S or CH 2 ; n is an integer of 1 to 5; R 1 is an unsubstituted or substituted heterocyclic group (where the heterocyclic group is a 5- or 6-membered heterocyclic group having 1 to 4 of O, S and N); R 2 is a group represented by the formula:
(where R 4 is an unsubstituted or substituted phenyl or 2-amino- thiazolyl) or a group represented by the formula:
(where R 5 is an unsubstituted or substituted lower alkyl); R 3 is hydrogen, an alkali metal, an alkaline earth metal, an organic ammonium group or an ester residue, and R 1 may be a quaternary ammonium group, where -CO 2 R 3 represents -CO 2 ] have strong antibacterial activity against Gram-positive and Gram-negative bacteria, and are useful for treating various infections.
[Wherein X is S or CH 2 ; n is an integer of 1 to 5; R 1 is an unsubstituted or substituted heterocyclic group (where the heterocyclic group is a 5- or 6-membered heterocyclic group having 1 to 4 of O, S and N); R 2 is a group represented by the formula:
(where R 4 is an unsubstituted or substituted phenyl or 2-amino- thiazolyl) or a group represented by the formula:
(where R 5 is an unsubstituted or substituted lower alkyl); R 3 is hydrogen, an alkali metal, an alkaline earth metal, an organic ammonium group or an ester residue, and R 1 may be a quaternary ammonium group, where -CO 2 R 3 represents -CO 2 ] have strong antibacterial activity against Gram-positive and Gram-negative bacteria, and are useful for treating various infections.
信息查询
