发明公开
EP0192404A2 Vaccine, method for its preparation and use thereof in vaccinating humans against rotavirus infection
失效
疫苗，准备同样的方法及其抗轮状病毒感染人类的疫苗接种。
- 专利标题： Vaccine, method for its preparation and use thereof in vaccinating humans against rotavirus infection
- 专利标题（中）： 疫苗，准备同样的方法及其抗轮状病毒感染人类的疫苗接种。
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申请号： EP86300941.1申请日： 1986-02-12
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公开(公告)号： EP0192404A2公开(公告)日： 1986-08-27
- 发明人: Plotkin, Stanley A. , Clark, H. Fred.
- 申请人： THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY
- 申请人地址： 36th & Spruce Streets Philadelphia, PA 19104 US
- 专利权人： THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY
- 当前专利权人： THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY
- 当前专利权人地址： 36th & Spruce Streets Philadelphia, PA 19104 US
- 代理机构： Hale, Stephen Geoffrey
- 优先权： US702041 19850215
- 主分类号： A61K39/12
- IPC分类号： A61K39/12
摘要：
A live rotavirus vaccine against bovine and human rotaviruses comprising a strain of live bovine rotavirus which does not hemagglutinate primate red blood cells, gives at least about 20 fold higher titers when neutralized with antiserum therefor as compared to heterologous bovine or primate rotaviruses, and has a migration pattern of its RNA genome segments when determined by PAGE substantially as shown by lane WC3 in Figure 1, the strain of bovine rotavirus having been serially passaged in primate kidney tissue culture a sufficient number of times that when administered to humans the vaccine is immunogenic without causing disease.
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