发明公开
EP0195078A4 BACILLUS STRAINS WITH REDUCED EXTRACELLULAR PROTEASE LEVELS.
失效
芽孢杆菌TRIBES具有降低的胞外蛋白酶MIRROR。
- 专利标题： BACILLUS STRAINS WITH REDUCED EXTRACELLULAR PROTEASE LEVELS.
- 专利标题（中）： 芽孢杆菌TRIBES具有降低的胞外蛋白酶MIRROR。
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申请号： EP85905017申请日： 1985-09-20
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公开(公告)号： EP0195078A4公开(公告)日： 1988-01-25
- 发明人: FAHNESTOCK STEPHEN R , FISHER KATHRYN E
- 申请人： GENEX CORP
- 专利权人： GENEX CORP
- 当前专利权人： GENEX CORP
- 优先权： US65296884 1984-09-21; US73337985 1985-05-13
- 主分类号： C12N9/56
- IPC分类号： C12N9/56 ; C12N15/75 ; C12N15/90 ; C12N1/20 ; C12N1/00 ; C12N9/48 ; C12N9/50 ; C12N9/52 ; C12N9/54 ; C12N15/00
摘要：
Bacillus strains having reduced levels of extracellular protease are produced by replacing the native chromosomal DNA sequence comprising the gene for an extracellular protease, such as subtilisin, with a partially homologous DNA sequence having an inactivating DNA segment inserted therein. The strains are useful as hosts for the expression and secretion of heterologous polypeptides or proteins.
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