发明授权
- 专利标题： NUCLEOTIDE ANALOGS FOR NUCLEIC ACID LABELING AND DETECTION
- 专利标题（中）： 用于核酸标记和检测的核苷酸模拟物
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申请号： EP85905977.6申请日： 1985-11-06
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公开(公告)号： EP0203959B1公开(公告)日： 1992-09-09
- 发明人: KLEVAN, Leonard , GEBEYEHU, Gulilat , RAO, Prasad, Y.
- 申请人： LIFE TECHNOLOGIES, INC.
- 申请人地址： 8717 Grovemont Circle Gaithersburg, MD 20877 US
- 专利权人： LIFE TECHNOLOGIES, INC.
- 当前专利权人： LIFE TECHNOLOGIES, INC.
- 当前专利权人地址： 8717 Grovemont Circle Gaithersburg, MD 20877 US
- 代理机构： Jacobacci, Filippo
- 优先权： US669334 19841108
- 国际公布： WO8602929 19860522
- 主分类号： C07H15/12
- IPC分类号： C07H15/12 ; C07H17/00
摘要：
Nucleotide analogs, modified by the attachment at hydrogen bonding positions of linker groups, that is, the 6-position of adenine, 4-position of cytosine, and 2-position of guanine, are prepared. Such analogs, alone or with reporter groups attached (Figure 1), may be incorporated into DNA probes which effectively hybridize adenine to target DNA. For example, Figure 1 shows adenine and cytosine analogs attached to a biotin reporter group.
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