发明授权
EP0203962B1 DIAMIDE-DTPA-PARAMAGNETIC CONTRAST AGENTS FOR MR IMAGING, APPARATUS AND METHODS
失效
用于磁共振成像的DIAMIDE-DTPA-PARAMAGNETIC对比剂,装置和方法
- 专利标题: DIAMIDE-DTPA-PARAMAGNETIC CONTRAST AGENTS FOR MR IMAGING, APPARATUS AND METHODS
- 专利标题(中): 用于磁共振成像的DIAMIDE-DTPA-PARAMAGNETIC对比剂,装置和方法
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申请号: EP85905998.2申请日: 1985-11-12
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公开(公告)号: EP0203962B1公开(公告)日: 1991-05-02
- 发明人: QUAY, Steven, G.
- 申请人: SALUTAR, INC.
- 申请人地址: 428 Oakmead Parkway Sunnyvale California 94086 US
- 专利权人: SALUTAR, INC.
- 当前专利权人: SALUTAR, INC.
- 当前专利权人地址: 428 Oakmead Parkway Sunnyvale California 94086 US
- 代理机构: Cockbain, Julian, Dr.
- 优先权: US671106 19841113
- 国际公布: WO8602841 19860522
- 主分类号: A61K49/00
- IPC分类号: A61K49/00 ; A61B5/05 ; C07F15/00
摘要:
Homologs of Diamide-DTPA-Paramagnetic compounds (such as diamido acetyl diethylene triamine triacetic acid) provide excellent contrast agents for magnetic resonance (MR) imaging. The magnetic dipole generated by the unpaired electron within the paramagnetic (PM) atom, causes a local reduction in the bulk magnetic field of the MR system. The resulting shortening of the T1 (spin lattice) relaxation time in the local hydrogen protons within the area of interest, causes an intense "free induction signal" and a corresponding modulation in the collected scanning data. The tissue or organ of interest appears on the MR display highlighted in white. Background tissue is displayed as darker or lower intensity greys. A surface highlighted image of the small and large intestine may be obtained by venous injection of the diamide contrast agent. The contrast agent is formed by replacing two carboxylic acids on the DTPA chelator with functional amide groups. The homologs enable the Diamide-DTPA-PM contrast agents to go into solution readily, and promote organ selectivity.
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