发明公开
EP0205025A1 Fluorine derivatives of vitamin D3 and cell differentiation-inducing agents containing the same as an active ingredient
失效
氟化物维生素D3-衍生物和Zelldifferenzierung induzierende Mittel，死亡的Wirkstoff呕吐物。
- 专利标题： Fluorine derivatives of vitamin D3 and cell differentiation-inducing agents containing the same as an active ingredient
- 专利标题（中）： 氟化物维生素D3-衍生物和Zelldifferenzierung induzierende Mittel，死亡的Wirkstoff呕吐物。
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申请号： EP86107131.4申请日： 1986-05-26
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公开(公告)号： EP0205025A1公开(公告)日： 1986-12-17
- 发明人: Morii, Hirotoshi , Hamma, Noritaka , Saito, Yoshikazu , Nishizawa, Toshio , Nagata, Akihiko
- 申请人： SUMITOMO PHARMACEUTICALS COMPANY, LIMITED , Morii, Hirotoshi
- 申请人地址： 2-8, Doshomachi 2-chome, Chuo-ku Osaka-shi Osaka-fu JP
- 专利权人： SUMITOMO PHARMACEUTICALS COMPANY, LIMITED,Morii, Hirotoshi
- 当前专利权人： SUMITOMO PHARMACEUTICALS COMPANY, LIMITED,Morii, Hirotoshi
- 当前专利权人地址： 2-8, Doshomachi 2-chome, Chuo-ku Osaka-shi Osaka-fu JP
- 代理机构： VOSSIUS & PARTNER
- 优先权： JP113866/85 19850527; JP73825/86 19860331
- 主分类号： C07C172/00
- IPC分类号： C07C172/00 ; A61K31/59 ; C07J9/00
摘要：
Described are novel compounds of the formula (IV)
wherein R 1 is a hydrogen atom, a nyaroxyl group or a protected hydroxyl group and R 2 is a hydrogen atom or a protecting group,
a pharmaceutical composition useful as a cell differentiation-inducing agent, which contains an effective amount of a compound of the formula IV (wherein R 2 is H) as an active ingredient and a pharmaceutically acceptable carrier or diluent,
a method of inducing cell differentiation by administering an effectiveamount of a compound of the formula IV (wherein R 2 is H to a patient,
and a proceesfor producing a compound of the formula (IV) by subjecting a previtamin D 3 derivative of the formula (III)
wherein R 1 and R 2 are as defined above, to thermal isomerization to yield a vitamin D 3 derivative of the formula (IV) mentioned above.
wherein R 1 is a hydrogen atom, a nyaroxyl group or a protected hydroxyl group and R 2 is a hydrogen atom or a protecting group,
a pharmaceutical composition useful as a cell differentiation-inducing agent, which contains an effective amount of a compound of the formula IV (wherein R 2 is H) as an active ingredient and a pharmaceutically acceptable carrier or diluent,
a method of inducing cell differentiation by administering an effectiveamount of a compound of the formula IV (wherein R 2 is H to a patient,
and a proceesfor producing a compound of the formula (IV) by subjecting a previtamin D 3 derivative of the formula (III)
wherein R 1 and R 2 are as defined above, to thermal isomerization to yield a vitamin D 3 derivative of the formula (IV) mentioned above.
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