发明授权
- 专利标题： PHYSICALLY MODIFIED BECLOMETHASONE DIPROPIONATE SUITABLE FOR USE IN AEROSOLS
- 专利标题（中）： 适用于气溶胶的物理改性的二氯甲烷
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申请号： EP86900210.5申请日： 1985-12-16
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公开(公告)号： EP0205530B1公开(公告)日： 1989-02-22
- 发明人: JINKS, Philip, Anthony
- 申请人： RIKER LABORATORIES, INC.
- 申请人地址： 19901 Nordhoff Street Northridge California US
- 专利权人： RIKER LABORATORIES, INC.
- 当前专利权人： RIKER LABORATORIES, INC.
- 当前专利权人地址： 19901 Nordhoff Street Northridge California US
- 代理机构： Bowman, Paul Alan
- 优先权： GB8432063 19841219
- 国际公布： WO8603750 19860703
- 主分类号： C07J5/00
- IPC分类号： C07J5/00 ; A61K9/72
摘要：
A method for preparing a stable aerosol formulation of beclomethasone dipropionate in which the steroid is contacted with an alcohol containing 1 to 5 carbon atoms to form a crystalline solvate therewith, the crystalline material so formed being reduced to a particle size below 10 microns and thereafter dispersed in a composition comprising chlorofluorocarbon propellents.
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